Ingefära och prostatacancer

Br J Nutr. 2012 Feb;107(4):473-84. doi: 10.1017/S0007114511003308. Epub 2011 Aug 18.

Benefits of whole ginger extract in prostate cancer.

Karna P, Chagani S, Gundala SR, Rida PC, Asif G, Sharma V, Gupta MV, Aneja R.

Source

Department of Biology, Georgia State University, Atlanta, GA 30303, USA.

Abstract

It is appreciated far and wide that increased and regular consumption of fruits and vegetables is linked with noteworthy anticancer benefits. Extensively consumed as a spice in foods and beverages worldwide, ginger (Zingiber officinale Roscoe) is an excellent source of several bioactive phenolics, including non-volatile pungent compounds such as gingerols, paradols, shogaols and gingerones. Ginger has been known to display anti-inflammatory, antioxidant and antiproliferative activities, indicating its promising role as a chemopreventive agent. Here, we show that whole ginger extract (GE) exerts significant growth-inhibitory and death-inductory effects in a spectrum of prostate cancer cells. Comprehensive studies have confirmed that GE perturbed cell-cycle progression, impaired reproductive capacity, modulated cell-cycle and apoptosis regulatory molecules and induced a caspase-driven, mitochondrially mediated apoptosis in human prostate cancer cells. Remarkably, daily oral feeding of 100 mg/kg body weight of GE inhibited growth and progression of PC-3 xenografts by approximately 56 % in nude mice, as shown by measurements of tumour volume. Tumour tissue from GE-treated mice showed reduced proliferation index and widespread apoptosis compared with controls, as determined by immunoblotting and immunohistochemical methods. Most importantly, GE did not exert any detectable toxicity in normal, rapidly dividing tissues such as gut and bone marrow. To the best of our knowledge, this is the first report to demonstrate the in vitro and in vivo anticancer activity of whole GE for the management of prostate cancer.

http://www.ncbi.nlm.nih.gov/pubmed/21849094

Forskningen går vidare...... ingefära har kända anti-inflammatoriska egenskaper och inger förhoppningar.

Har även läst att den kan ha viss effekt på äggstockscancer. 

Följer denna utveckling med stort intresse.

Gardasil samma skydd för alla?

Vilka HPV virus strängar kan egentligen orsaka livmoderhalscancer?
Får alla samma skydd som blir vaccinerade?

Dagens HPV vaccin skyddar inte fullt ut vilket många tror. Det finns fortfarande en stor chans att drabbas av livmoderhalscancer eftersom det endast skyddar mot vissa av de strängar som anses kunna orsaka cancer.
Så det är fortfarande jätteviktigt att gå på regelbundna cellprovstagningar.

Ett nytt vaccin håller för närvarande på att testas, detta riktar sig emot 9 olika HPV strängar. Ytterligare studier krävs.

Public release date:

28-Oct-2013

HPV strains affecting African-American women differ from vaccines

NATIONAL HARBOR, M.D. – Two subtypes of human papillomavirus (HPV) prevented by vaccines are half as likely to be found in African-American women as in white women with precancerous cervical lesions, according to researchers at Duke Medicine.

The findings, presented on Oct. 28, 2013, at the 12th annual International Conference on Frontiers in Cancer Prevention Research hosted by the American Association for Cancer Research, suggest that African-American women may be less likely to benefit from available HPV vaccines to prevent cervical cancer.

HPV is a common sexually transmitted infection with more than 40 subtypes. The virus causes nearly all cases of cervical cancer, which begin as precancerous cervical abnormalities. 

Two vaccines currently available to young women prevent infection by HPV 16 and HPV 18, the HPV strains responsible for about 70 percent cervical cancers.

"Screening programs for cervical cancer are known to work well, with around 90 percent of sexually active women getting screened through Pap tests," said senior author Cathrine Hoyo, Ph.D., M.P.H., associate professor of obstetrics and gynecology at Duke University School of Medicine.

"The question is, if screening rates are comparable in African-American and white women, why are the rates of cervical cancer and mortality higher among African-American women when we have a program that works so well?"

Hoyo and her colleagues sought to better understand these disparities by determining if African-American and white women in the U.S. are infected with the same subtypes of HPV. The researchers enrolled 572 participants -- 280 African-American women and 292 non-Hispanic white women -- who came for additional testing after receiving abnormal Pap test results.

Of the 572 participants, 245 (43 percent) had no precancerous cervical abnormalities, 239 (42 percent) had early precancerous cervical abnormalities, and 88 (15 percent) had advanced precancerous cervical abnormalities. Seventy-three percent of the women infected with HPV were infected with multiple HPV subtypes.

When the researchers looked at the specific strains of HPV, they found that white women and African-American women were often infected with different subtypes. The most frequent HPV subtypes detected among white women with early precancerous cervical abnormalities were 16, 18, 56, 39 and 66, while HPV subtypes 33, 35, 58 and 68 were the most common ones detected in African-Americans.

In those with advanced precancerous cervical abnormalities, HPV 16, 18, 33, 39 and 59 were the most common genotypes detected in white women, whereas HPV 31, 35, 45, 56, 58, 66 and 68 were the most prevalent in African-American women.

"Compared with white women, we saw that African-American women had about half as many infections with HPV 16 and 18, the subtypes that are covered by HPV vaccines," said Adriana Vidal, Ph.D., assistant professor of obstetrics and gynecology at Duke University School of Medicine and the study's first author. "Since African-American women don't seem to be getting the same subtypes of HPV with the same frequency, the vaccines aren't helping all women equally."

A new HPV vaccine targeting nine HPV subtypes (6, 11, 16, 18, 31, 33, 45, 52 and 58) is currently being tested in phase III trials. While the new vaccine may help prevent additional HPV infections by covering new subtypes, it may not address the disparities found in this study.

"The most disconcerting part of this new vaccine is it doesn't include HPV 35, 66 and 68, three of the strains of HPV of which African-American women are getting the most," Hoyo said. "We may want to rethink how we develop these vaccines, given that African-Americans tend to be underrepresented in clinical trials."

The researchers noted that while these findings are compelling, the results are preliminary and the studies should be replicated in larger populations. Hoyo, Vidal and their colleagues are also continuing the research to define epigenetic marks that can be used to predict which precancerous cervical abnormalities will advance.

###

In additional to Hoyo and Vidal, study authors from Duke include Fidel Valea, Anne Ford, Francine Overcash and Susan K. Murphy of the Department of Obstetrics and Gynecology; Rex Bentley and Katherine Grant of the Department of Pathology; and Maggie Gradison and Kimberly S. H. Yarnall of the Department of Community and Family Medicine. Jennifer S. Smith of the Department of Epidemiology at Gillings School of Global Public Health at the University of North Carolina at Chapel Hill also contributed to the research.

The research was supported by the National Cancer Institute (R01CA142983 and R01CA142983-02S1). The authors reported no conflicts of interest.

http://www.eurekalert.org/pub_releases/2013-10/dumc-


http://nymag.com/thecut/2013/10/hpv-vaccine-might-not-protect-black-women.html

Förgiftat hundgodis? Varning

USA today video

The Food and Drug Administration is asking pet owners and veterinarians to help solve a mystery: Why have jerky treats coming mostly from China sickened more than 3,600 dogs and cats and killed at least 580 of them since 2007?

The number of illnesses and deaths — the vast majority of which have affected dogs — has risen since January.

What the pets have in common: They became ill, usually within hours, after consuming treats sold as jerky tenders or strips. The treats are made of chicken, duck, sweet potatoes or dried fruit. Typical symptoms include decreased appetite and activity, vomiting, diarrhea, increased water consumption and increased urination. Some affected pets suffer kidney failure.

Varningen gäller torkat hundgodis ifrån Kina. Titta ordentligt på påsarna och välj endast de varor som har angivit tillverkningsland. Nestle är en av tillverkarna.

Autism länkat till vaccin i 28 studier

http://healthimpactnews.com/2013/new-published-study-verifies-andrew-wakefields-research-on-autism-again/


And today, scientists and physicians from Wake Forest University, New York, and Venezuela, reported findings that not only confirm the presence of intestinal disease in children with autism and intestinal symptoms, but also indicate that this disease may be novel. [viii] Using sophisticated laboratory methods Dr. Steve Walker and his colleagues endorsed Wakefield’s original findings by showing molecular changes in the children’s intestinal tissues that were highly distinctive and clearly abnormal.

From 1998 Dr. Wakefield discovered and reported intestinal disease in children with autism. [ix] Based upon the medical histories of the children he linked their disease and their autistic regression to the Measles, Mumps, Rubella (MMR vaccine). He has since been subjected to relentless personal and professional attacks in the media, and from governments, doctors and the pharmaceutical industry. In the wake of demonstrably false and highly damaging allegations of scientific fraud by British journalist Brian Deer and the British Medical Journal, Dr. Wakefield is pursuing defamation proceedings against them in Texas. [x]

While repeated studies from around the world confirmed Wakefield’s bowel disease in autistic children [xi] and his position that safety studies of the MMR are inadequate, [xii] Dr. Wakefield ’s career has been destroyed by false allegations.  Despite this he continues to work tirelessly to help solve the autism catastrophe.

The incidence of autism has rocketed to a risk of around 1 in 25 for children born today. Mean while governments, absent any explanation and fearing loss of public trust, continue to deny the vaccine autism connection despite the concessions in vaccine court.

Speaking from his home in Austin, Texas, Dr. Wakefield said, 
There can be very little doubt that vaccines can and do cause autism. In these children, the evidence for a n adverse reaction involving brain injury following the MMR that progresses to an autism diagnosis is compelling. It’s now a question of the body count. The parents’ story was right all along. Governments must stop playing with words while children continue to be damaged . My hope is that recognition of the intestinal disease in these children will lead to the relief of their suffering. This is long , long overdue .”

Artikeln innehåller även en video samt en lista över 28 vetenskapliga studier, utförda i hela världen och som alla stödjer Dr Wakefield’s forskning.


Jag befann mig i USA 1998 och försökte följa alla vetenskapliga program samt de rättegångar i ämnet som sändes på C-span. Läkare som uttryckte sin förtvivlan över de inflammationsskador de funnit hos barn i deras tarmar. Påståenden som specialister och läkemedelsföretagens advokater satt och flinade åt samtidigt som de mer eller mindre omyndighetsförklarade de stackars läkare som vågade tala ut med risk för att bli av med sin läkarleg för all framtid.

Långt ifrån alla som drabbats kommer att få ersättning ty så fungerar systemet. Ett fåtal får ersättning och sedan friskrivs tillverkaren. Kvar sitter föräldrar och de drabbade autiska barnen.

Men som sagt.... detta krig kommer att fortsätta i all evighet för det kommer alltid att finnas två sidor, en som säger att det är ofarligt och en annan som säger att det är farligt. Man kan kalla det för balans eller spelet på marknaden.

Vad man skall välja är vad som är bäst för individen, för familjen, i den situation de befinner sig i. Allt är ett risktagande, ett val som måste göras och vi kan bara göra vårt bästa.

GMO världen och dess nya skapelser

Lite humor med en stor portion sanning..... eller?

GMO foder ger skador på grismagar...

Någon efterfrågade en peer-reviewed studie och här kommer en av alla som finns ute på nätet.

http://gmojudycarman.org/



Grisarna har blivit utfodrande med genmodifierad soja och majs.


Dr. Judy Carman, associate professor in Health and the Environment at Flinders University (Adelaide, South Australia) and a team of seven other co-authors and scientists have released results of a long-term, peer-reviewed toxicology study that has found even more adverse effects resulting from the consumption of genetically modified foods.


Using 168 just-weaned piglets from a commercial pig farm located in the United States, researchers fed half the subjects a mixed diet of widely-used varieties of GM maize (corn) and soy. The other half—the control group—were fed an equivalent non-GM diet.
Pigs were specifically chosen as the test animal since their digestive system is similar to that of humans. Another factor was that investigators in the past had observed both digestive and reproductive problems in pigs fed GM crops, so this provided a basis for further scientific investigation.


 Dr. Carman and her team discovered a 25% increase in uterus weight in the animals fed the GM diet as compared to the control group.  In addition, GM-fed male pigs were four times more likely to be afflicted with severe stomach inflammation, while females had more than double the risk of the control group.
The doctor emphasized that both the uterus and stomach findings were biologically and statistically significant.  There was also a “marginally significant change on a measure of liver health in the blood of GM-fed pigs.”

 

 

 

ingen cohort studie här inte.......

 

Round-up ger DNA skador på fisk

Genotoxic effects of the herbicide Roundup(®) in the fish Corydoras paleatus (Jenyns 1842) after short-term, environmentally low concentration exposure.

de Castilhos Ghisi N, Cestari MM.

Source
GMO-frönas aktivator även kallat för bekämpningsmedel: Round-up

ger skador på fisk DNA vid låga kvantiteter.

När våra åkrar dränks med Round-up så rinner det ner i grundvattnet

och vad händer sedan?

　

http://www.ncbi.nlm.nih.gov/pubmed/22821326

　

　

Programa de Pós-Graduação em Ecologia de Ambientes Aquáticos Continentais, Universidade Estadual de Maringá, Av Colombo, 5790 Bloco G-90, sala 16, Jardim Universitário, 87020-900 Maringá, Paraná, Brazil. nediaghisi@gmail.com



Abstract
The glyphosate-based herbicide, Roundup(®), is one of the most used pesticides worldwide. In concert with the advent of transgenic crops resistant to glyphosate, the use of this pesticide has led to an increase in agricultural yields. The objective of this study was to evaluate the genotoxic effect that the herbicide Roundup(®) (at a concentration of 6.67 μg/L, corresponding to 3.20 μg/L glyphosate) can have on the fish Corydoras paleatus. Treatment groups were exposed for 3, 6, and 9 days, and effects were analyzed using the piscine micronucleus test (PMT) and comet assay. A group subjected to filtered water only was used as a negative control. The PMT did not show differences between the control and exposed groups for any of the treatment times. In contrast, the comet assay showed a high rate of DNA damage in group exposed to Roundup(®) for all treatment times, both for blood and hepatic cells. We conclude that for the low concentration used in this research, the herbicide shows potential genotoxic effects. Future research will be important in evaluating the effects of this substance, whose presence in the environment is ever-increasing.