Reviewed by Robert Jasmer, MD; Associate Clinical Professor of Medicine, University of California, San Francisco
Greater urinary concentration of BPA in children, commonly found in food and drink packaging, was significantly associated with higher risk of obesity, as well as greater odds of an abnormal waist circumference.
Note that another study found that increased concentration of the plasticizer DEHP in the urine of adolescents was associated with an increased risk for insulin resistance.
Urinary concentrations of two chemicals commonly found in food packaging -- bisphenol A (BPA) and di-2-ethylhexyl phthalate (DEHP) -- were associated with risks for obesity in children and insulin resistance in teens, two studies showed.
In one study, greater urinary concentration of BPA, commonly found in food and drink packaging, was significantly associated with higher risk of body mass index (BMI) in the 95th percentile or greater, as well as greater odds of an abnormal waist circumference-to-height ratio, according to Joyce Lee, MD, of the Child Health Evaluation and Research Unit at the University of Michigan in Ann Arbor, and colleagues.
Another study of adolescent exposure to the plasticizer di-2-ethylhexyl phthalate (DEHP) showed that each three-fold increased concentration of the chemical in urine was associated with a 27% increased risk for insulin resistance, reportedLeonardo Trasande, MD, of New York University's Langone Medical Center in New York City, and colleagues. Both studies appear in the journal Pediatrics.
DEHP is another chemical compound found in plastics used in the manufacture of food and drink containers.
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The study by Lee's group was funded by the NIH and supported by the Department of Pediatrics and the Ofﬁce of the Vice President of Research, University of Michigan. One co-author received a training grant from the National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases and the U.S. Environmental Protection Agency.